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orgavaa/README.md

Biologist working at the intersection of experimental cell biology and computational modeling.

Training spans immunology, biologics, and bioprocessing across research institutions and biopharma (IBS, Sanofi, Lonza), with hands-on experience from primary cell isolation and flow cytometry to GMP-grade protein purification and single-cell transcriptomics. I build projects that turn complex biological data — single-cell, sequence, imaging, spatial — into interpretable systems that sharpen hypotheses, guide experiments, and accelerate translation.

Co-founder of Holocyte — a research lab developing JEPA-based world models for single-cell perturbation prediction, aimed at reducing the experimental search space in drug discovery.

Research interests

  • Cell mechanobiology and glycobiology — how glycocalyx composition, conformation, and remodeling participate in mechanotransduction, and how this feedback shapes disease progression in fibrosis.
  • Quantitative phenotyping from microscopy — open-source pipelines that extract interpretable per-cell features (glycocalyx organization, YAP localization, focal adhesion morphology, cytoskeletal organization) for cross-condition comparison in perturbation biology.
  • Foundation models for cellular response — self-supervised architectures (JEPA, GNN, protein language models) for predicting how cells respond to genetic, chemical, and mechanical perturbations from single-cell and sequence data.
  • Translational bioengineering — integrating computational models with experimental workflows to move quantitative tools from the lab toward disease models and drug screening platforms.

Pinned Loading

  1. structural-antibody-binding-gnn structural-antibody-binding-gnn Public

    Predicting how point mutations change antibody–antigen binding affinity (ΔΔG) is central to affinity maturation and developability. This repo explores how far you can go with simple sequence/linear…

    Python 2

  2. B-jepa B-jepa Public

    Python 2