diff --git a/Lib/test/test_capi/test_opt.py b/Lib/test/test_capi/test_opt.py
index 437cc340fc90e3..9463e5d5594d47 100644
--- a/Lib/test/test_capi/test_opt.py
+++ b/Lib/test/test_capi/test_opt.py
@@ -2030,6 +2030,23 @@ def f(n):
         self.assertNotIn("_GUARD_NOS_TUPLE", uops)
         self.assertIn("_BINARY_OP_SUBSCR_TUPLE_INT", uops)
 
+    def test_remove_guard_for_known_type_slice(self):
+        def f(n):
+            x = 0
+            for _ in range(n):
+                l = [1, 2, 3]
+                slice_obj = slice(0, 1)
+                x += l[slice_obj][0] # guarded
+                x += l[slice_obj][0] # unguarded
+            return x
+        res, ex = self._run_with_optimizer(f, TIER2_THRESHOLD)
+        self.assertEqual(res, TIER2_THRESHOLD * 2)
+        uops = get_opnames(ex)
+
+        count = count_ops(ex, "_GUARD_TOS_SLICE")
+        self.assertEqual(count, 1)
+        self.assertIn("_BINARY_OP_SUBSCR_LIST_INT", uops)
+
     def test_remove_guard_for_tuple_bounds_check(self):
         def f(n):
             x = 0
diff --git a/Misc/NEWS.d/next/Core_and_Builtins/2026-02-04-12-19-48.gh-issue-131798.My5jLy.rst b/Misc/NEWS.d/next/Core_and_Builtins/2026-02-04-12-19-48.gh-issue-131798.My5jLy.rst
new file mode 100644
index 00000000000000..849889f81fc323
--- /dev/null
+++ b/Misc/NEWS.d/next/Core_and_Builtins/2026-02-04-12-19-48.gh-issue-131798.My5jLy.rst
@@ -0,0 +1 @@
+Optimise ``_GUARD_TOS_SLICE`` in the JIT.
diff --git a/Python/optimizer_bytecodes.c b/Python/optimizer_bytecodes.c
index 89c6707160326c..3a2af7d9198175 100644
--- a/Python/optimizer_bytecodes.c
+++ b/Python/optimizer_bytecodes.c
@@ -1417,6 +1417,13 @@ dummy_func(void) {
         }
     }
 
+    op(_GUARD_TOS_SLICE, (tos -- tos)){
+        if (sym_matches_type(tos, &PySlice_Type)){
+            ADD_OP(_NOP, 0, 0);
+        }
+        sym_set_type(tos, &PySlice_Type);
+    }
+
     op(_GUARD_NOS_NULL, (null, unused -- null, unused)) {
         if (sym_is_null(null)) {
             ADD_OP(_NOP, 0, 0);
diff --git a/Python/optimizer_cases.c.h b/Python/optimizer_cases.c.h
index 61a30314c21789..259cf2a1c32dc7 100644
--- a/Python/optimizer_cases.c.h
+++ b/Python/optimizer_cases.c.h
@@ -370,6 +370,12 @@
         }
 
         case _GUARD_TOS_SLICE: {
+            JitOptRef tos;
+            tos = stack_pointer[-1];
+            if (sym_matches_type(tos, &PySlice_Type)){
+                ADD_OP(_NOP, 0, 0);
+            }
+            sym_set_type(tos, &PySlice_Type);
             break;
         }