diff --git a/tests/unit/vertexai/genai/test_genai_client.py b/tests/unit/vertexai/genai/test_genai_client.py
index 16c7068b78..cd600df56d 100644
--- a/tests/unit/vertexai/genai/test_genai_client.py
+++ b/tests/unit/vertexai/genai/test_genai_client.py
@@ -52,6 +52,13 @@ def test_genai_client(self):
         assert test_client._api_client.project == _TEST_PROJECT
         assert test_client._api_client.location == _TEST_LOCATION
 
+    @pytest.mark.parametrize("location", ["us", "eu"])
+    @pytest.mark.usefixtures("google_auth_mock")
+    def test_genai_client_mrep(self, location):
+        test_client = vertexai.Client(project=_TEST_PROJECT, location=location)
+        expected_url = f"https://aiplatform.{location}.rep.googleapis.com/"
+        assert test_client._api_client._http_options.base_url == expected_url
+
     @pytest.mark.asyncio
     @pytest.mark.usefixtures("google_auth_mock")
     async def test_async_client(self):
diff --git a/vertexai/_genai/client.py b/vertexai/_genai/client.py
index 77d8a9aadc..f16c2d50ed 100644
--- a/vertexai/_genai/client.py
+++ b/vertexai/_genai/client.py
@@ -219,6 +219,10 @@ def __init__(
         if http_options.headers is None:
             http_options.headers = {}
 
+        # Set the base URL for MREP locations.
+        if location in ["us", "eu"] and not http_options.base_url:
+            http_options.base_url = f"https://aiplatform.{location}.rep.googleapis.com/"
+
         tracking_label = f"{_GENAI_MODULES_TELEMETRY_HEADER}/{aip_version.__version__}"
 
         if "user-agent" in http_options.headers: