A potential source of false-positive homotypic inter-protein crosslinks arising from gas-phase adduct formation during mass spectrometry. These events can mimic true homomeric interaction signals and may lead to inflated homodimer identification rates in downstream analyses.
We would like to open a discussion with the community to explore systematic ways to detect and filter these artifacts programmatically.
A potential source of false-positive homotypic inter-protein crosslinks arising from gas-phase adduct formation during mass spectrometry. These events can mimic true homomeric interaction signals and may lead to inflated homodimer identification rates in downstream analyses.
We would like to open a discussion with the community to explore systematic ways to detect and filter these artifacts programmatically.